Abstract
The incidence of overweight and obesity in the Mexican population has increased above 70%, mainly driven by a HFHC diet. The objective of the present study was to investigate the biochemical, cognitive and histological effects of the hypercaloric diet. 12 mice of the BALB/c strain were divided into 2 groups: the control group and the treatment group. For 7 months the control group was administered a standard diet with pellets and the experimental group a HFHC diet. Bromatological tests were performed on the diet twice, as well as biochemical and cognitive tests on the mice. On the 7th month they were sacrificed and a histological analysis of the liver, kidney, heart, lung, adipose tissue and brain was performed. Lipid droplets were found in the liver, compact glomeruli and thickened renal tubes were found in the kidneys, wall thickening and decreased vascular lumen were found in the heart. In the brain, marked cellular damage possibly consistent with apoptosis due to intraneuronal amyloid formation was found in treated mice compared to controls, which may be related to the results of cognitive tests towards memory loss. These findings suggest that the HFHC diet negatively affects the morphology of the digestive, metabolic and central nervous system organs, before biochemical and motor alterations appear.
Presenters
Daniela Ortiz QuiñonesStudent, Bachelor's Degree in Nutrition, Universidad de Monterrey, Mexico Cynthia Rosales
Student, B.S. in Nutrition, Universidad de Monterrey, Mexico
Details
Presentation Type
Paper Presentation in a Themed Session
Theme
KEYWORDS
Hypercaloric diet, Morphology, Cognitive, Memory, Neurodegenerative diseases, Obesity, Nutrition, Experiment
