Evidence-informed Approach to De-prescribing of Atypical Antipsychotics in the Management of Behavioral Expressions in Advanced Neurocognitive Disorders: Results of a Retrospective Study

Abstract

LuBAIRâ„¢ Paradigm, a novel approach to ascribing meaning for behavioral expression in advanced neurocognitive disorder, was used to identify behavioral categories that are likely to respond to the use of atypical antipsychotics in their management. LuBAIRâ„¢ Inventory filled on two occasions. The data collected on the second occasion, in the successful and failed de-prescribed groups, were compared in this retrospective study. Chi-Square paired t-test and Cohen d Statistical tests were used to detect the difference in the behavioral categories between the two cohorts. Patients who did not have Mis-Identification and Goal-Directed Expressions were more likely to successfully de-prescribe : X2 (1, N = 40) = 29.119 p<.0001 and X2 (1, N = 40) = 32.374, p<.0001, respectively. Alternatively, the same behavioral categories were more likely to be present in patients who failed de-prescribing: paired t-test and Cohen-d (P<0.0001). Atypical antipsychotics, in their role as an antipsychotic and mood stabilizer, may be used to manage Mis-Identification and Goal-Directed Expressions, respectively.

Presenters

Atul Sunny Luthra
Psychiatrist, Medical Coordinator, Program for Older Adults, Homewood Health Centre, Ontario, Canada

Details

Presentation Type

Paper Presentation in a Themed Session

Theme

Mainstreaming Aging

KEYWORDS

NEUROCOGNITVE DISORDERS, BEHAVIORAL EXPRESSIONS, ATYPICAL ANTIPSYCHOTIC MEDICATIONS, LUBAIR PARADIGM