Abstract

Improving health and nutrition has led to a significant increase in life expectancy around the world. Aging is associated with an increase in age-related diseases. The use of metformin (Met) as an anti-aging drug has recently been proposed based on its widespread use in clinical practice. Reports have shown that Met acts as an anti-aging agent. In this study, the effects of long-term, one year, Met administration on aging-related behaviors and longevity in ovariectomized mice was studied. Met (1 and 10 mg/kg) was used daily in ovariectomized mice. The anxiety-like behavior, working memory, and physical strength were measured through elevated plus maze, Y-maze, vertical grid holding, and the obligatory swimming capacity tests. Brains were harvested to measure brain derived neurotrophic factor (BDNF) level. Also, the Kaplan-Meier survival curves were used to show differences and similarities in survival patterns. Met (10 mg/kg) decreased anxiety-like behaviors as well as increased muscle strength and working memory in the ovariectomized mice. Moreover, Met increased the physical strength and longevity as well as the level of BDNF in the ovariectomized mice. Our results indicate that the use of Met may be an effective strategy for the prevention and treatment of aging in the absence of female gonadal hormones which intern may exacerbate aging related disorders.

Presenters

Mohammad Allahtavakoli
Professor of Medical Physiology and Head of Department, Physiology and Pharmacology, Rafsanjan University of Medical wciences, Kerman, Iran

Details

Presentation Type

Paper Presentation in a Themed Session

Theme

Medical Perspectives on Aging, Health, Wellness

KEYWORDS

Metformin, Aging, Rodents, BDNF

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