Tenth International Conference on Health, Wellness & Society

Abstract

Preformulation studies depend on good flowability of powder. Lubricants have small appearance, but act as a big frame in flow behaviour during preparation of dosage form. Different lubricants such as magnesium stearate, sodium stearyl fumarate (SSF), and talc were evaluated and compared. Traditional methods, the results varied during the preparation of final dosage form like dissolution, content uniformity etc. PFT which performed the entire test in both consolidation and normal stress. Also traces the unconfined failular strength that is failed to consolidation. All the raw materials were found in cohesive region in flow function test from 0 to 9 kPa consolidated stress, although confined failure strengths were different for all. Density and internal frictional angle results were comply with flow function test. Agglomeration of powder into granules and addition of lubricants improve the flow behaviour respectively. The Hydrophilic nature of SSF was improving the nature of flow pattern and also synergistic impact on evaluation of final dosage form among all. Advance parameter i.e. Hopper design was plotted which specify flow pattern of granules in hopper to die cavity at the time of manufacturing. SSF was shown 220 hopper half angle at 0.29 m outlet dimension and 0.45 m rat hole diameter at 0.8 m powder depth. These results were best among all. PFT was found best suitable advance technique which mimics the loopholes in traditional and explores micro functions of powder. Ultimately this techniques help to design, choose suitable ingredient, reduce time and cost, and improve the health of society.