Microbial Centric Aging - A Paradym Shift

By: John Thomas  

We created in 2015 our Microbial Clock to address a common pathway for eight, costly, chronic diseases, unmasking six phyla, divided by four age categories, 0-100 years via review of 310 published manuscripts. In 2016, we added our Hologenomic Center for Clinical Studies (, to link our Clock with the emerging human microbiota and its co-evolution as “dual citizens” with combined genetic strength (Hologenome) greater than humans. We focused on the “infant microbiota” vs “aged microbiota”, unmasking a loss of phyla. Here, we describe the integration of the Biologic Clock with our Microbial Clock, the former the Nobel recipient for 2017, which focused on a twenty-four hour. clock, circadian with night and day, driven by a PERIOD gene. Together, the two human clocks gave emphasis to microbial partnership in diseases. The announcement by the NIH, echoing the European theme in 2016, that aging should be classified as a disease, heightened awareness of aging as a target for Replacement Therapy, strengthening genetic information exchange. The combined Clocks also provided a unique opportunity for the use of psychobiotics for AD, matched to 1) age, 2) WHO Region, and 3) ethnicity after review of sixty-seven additional manuscripts, thirty-five chosen, using our Partners-for -Life Decision Tree, ( Our continued theme was that our microbial wealth, defined by our microbial portfolio and the Hologenome, was an integral part of who we are as we age, and to ignore its genetic contribution, gains or losses, unscientific at the least, and confounding at best.

Hologeneome, Pychobiotics, Microbiota, Hologenomic Theory, Biologic Clock
Medical Perspectives on Aging, Health, Wellness
Virtual Poster

Prof. John Thomas

International educator and global microbiologist for 51 years in both dental and medical translational research . Director of hospital microbiology laboratories , followed by evolution into biofilm studies emphasizing endotrachs in mechanical ventilation and ventilator associated pneumonia (VAP) in adults, first, then NICU. Linked biofilm 3-D structure in oral health/endotrachs to chronic wounds and potential eco friendly management via probiotics , reestablishing restorative microbiology and protective biofilms . Unmasked dental/oral contribution to VAP using molecular methods well established at Cardiff University , on 6 moth sabbatical . Presently as Professor Emeritus , continuing research on chronic wounds and probiotics , integrating 3-D-bioprinting .