Abstract

Metformin and acetylsalicylic acid, two drugs that have been used in medicine for many years, are suspected to be geroprotectors, according to experimental research. Clinical observations of the drugs are compatible with the extension of geroprotective conditions to humans. In this study, we compared the variation of two parameters in blood chemistry that have been reported as markers of anti-aging activity, measured in people who had been treated for five years with one or two of these drugs. Also, we reviewed the metabolic targets of the drugs to support their effectiveness in anti-aging and the prevention of aging-associated diseases. In conclusion, the groups of forty people who were treated for five years with low doses of metformin, acetylsalicylic acid, or both, experienced significant decreases in glycosylated hemoglobin and ferritin, in comparison to a non-treated group. At the end of the five-year period, the number of living individuals in the non-treated group was minimal, higher in the groups treated with metformin or acetylsalicylic acid, and highest in the group treated with both drugs together.